Frozen tissue research

Representative publications related to the resource

Li Q, Bozek K, Xu C, Guo Y, Sun J, Pääbo S, Sherwood CC, Hof PR, Ely JJ, Li Y, Willmitzer L, Giavalisco P, Khaitovich P. 2017. Changes in lipidome composition during brain development in humans, chimpanzees, and macaque monkeys. Mol Biol Evol, 34(5):1155-1166 

Duka T, Collins Z, Anderson SM, Raghanti MA, Ely JJ, Hof PR, Wildman DE, Goodman M, Grossman LI, Sherwood CC. 2017. Divergent lactate dehydrogenase isoenzyme profile in cellular compartments of primate forebrain structures. Mol Cell Neurosci, 82:137-142

Liu X, Han D, Somel M, Jiang X, Hu H, Guijarro P, Zhang N, Mitchell A, Halene T, Ely JJ, Sherwood CC, Hof PR, Qiu Z, Pääbo S, Akbarian S, Khaitovich P. 2016. Disruption of an evolutionarily novel synaptic expression pattern in autism. PLoS Biol, 14(9):e1002558

Mendizabal I, Shi L, Keller TE, Konopka G, Preuss TM, Hsieh TF, Hu E, Zhang Z, Su B, Yi SV. 2016. Comparative methylome analyses identify epigenetic regulatory loci of human brain evolution. Mol Biol Evol, 33(11): 2947-2959

Bauernfeind AL, Soderblom EJ, Turner ME, Moseley MA, Ely JJ, Hof PR, Sherwood CC, Wray GA, Babbitt CC. 2015. Evolutionary divergence of gene and protein expression in the brains of humans and chimpanzees. Genome Biol Evol, 7(8): 2276-88

Bozek K, Wei Y, Yan Z, Liu X, Xiong J, Sugimoto M, Tomita M, Pääbo S, Sherwood CC, Hof PR, Ely JJ, Li Y, Steinhauser D, Willmitzer L, Giavalisco P, Khaitovich P. 2015. Organization and evolution of brain lipidome revealed by large-scale analysis of human, chimpanzee, macaque, and mouse tissues. Neuron, 85(4):695-702

Muntané G, Horvath JE, Hof PR, Ely JJ, Hopkins WD, Raghanti MA, Lewandowski AH, Wray GA, Sherwood CC. 2015. Analysis of synaptic gene expression in the neocortex of primates reveals evolutionary changes in glutamatergic neurotransmission. Cereb Cortex, 25(6):1596-607

Bauernfeind AL, Barks SK, Duka T, Grossman LI, Hof PR, Sherwood CC. 2014. Aerobic glycolysis in the primate brain: reconsidering the implications for growth and maintenance. Brain Struct Funct, 219(4): 1149-67

Duka T, Anderson SM, Collins Z, Raghanti MA, Ely JJ, Hof PR, Wildman DE, Goodman M, Grossman LI, Sherwood CC. 2014. Synaptosomal lactate dehydrogenase isoenzyme composition is shifted toward aerobic forms in primate brain evolution. Brain Behav Evol, 83(3):216-30

Konopka G, Friedrich T, Davis-Turak J, Winden K, Oldham MC, Gao F, Chen L, Wang GZ, Luo R, Preuss TM, Geschwind DH. 2012. Human-specific transcriptional networks in the brain. Neuron, 75(4):601-17

Zeng J, Konopka G, Hunt BG, Preuss TM, Geschwind D, Yi SV. 2012. Divergent whole-genome methylation maps of human and chimpanzee brains reveal epigenetic basis of human regulatory evolution. Am J Hum Genet, 91(3): 455-65

Konopka G, Bomar JM, Winden K, Coppola G, Jonsson ZO, Gao F, Peng S, Preuss TM, Wohlschlegel JA, Geschwind DH. 2009. Human-specific transcriptional regulation of CNS development genes by FOXP2. Nature, 462(7270):213-7

Uddin M, Opazo JC, Wildman DE, Sherwood CC, Hof PR, Goodman M, Grossman LI. 2008. Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates. BMC Evol Biol, 8:8

Calarco JA, Xing Y, Cáceres M, Calarco JP, Xiao X, Pan Q, Lee C, Preuss TM, Blencowe BJ. 2007. Global analysis of alternative splicing differences between humans and chimpanzees. Genes Dev, 21(22):2963-75

Marquès-Bonet T, Cáceres M, Bertranpetit J, Preuss TM, Thomas JW, Navarro A. 2004. Chromosomal rearrangements and the genomic distribution of gene-expression divergence in humans and chimpanzees. Trends Genet, 20(11):524-9

Cáceres M, Lachuer J, Zapala MA, Redmond JC, Kudo L, Geschwind DH, Lockhart DJ, Preuss TM, Barlow C. 2003. Elevated gene expression levels distinguish human from non-human primate brains. Proc Natl Acad Sci USA, 100(22):13030-5

National Chimpanzee Brain Resource
supported by NIH - National Institute of
Neurological Disorders and Stroke

The George Washington University
Georgia State University
Yerkes National Primate Research Center

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