Frozen tissue research
Representative publications related to the resource
Caglayan E, Ayhan F, Liu Y, Vollmer RM, Oh E, Sherwood CC, Preuss TM, Yi SV, Konopka G. 2023. Molecular features driving cellular complexity of human brain evolution. Nature. 620(7972):145-153.
Ma S, Skarica M, Li Q, Xu C, Risgaard RD, Tebbenkamp ATN, Mato-Blanco X, Kovner R, Krsnik Ž, de Martin X, Luria V, Martí-Pérez X, Liang D, Karger A, Schmidt DK, Gomez-Sanchez Z, Qi C, Gobeske KT, Pochareddy S, Debnath A, Hottman CJ, Spurrier J, Teo L, Boghdadi AG, Homman-Ludiye J, Ely JJ, Daadi EW, Mi D, Daadi M, Marín O, Hof PR, Rasin MR, Bourne J, Sherwood CC, Santpere G, Girgenti MJ, Strittmatter SM, Sousa AMM, Sestan N. 2022. Molecular and cellular evolution of the primate dorsolateral prefrontal cortex. Science. 377(6614):eabo7257.
Guevara EE, Hopkins WD, Hof PR, Ely JJ, Bradley BJ, Sherwood CC. 2022. Epigenetic ageing of the prefrontal cortex and cerebellum in humans and chimpanzees. Epigenetics. 17(12):1774-1785.
Staes N, White CM, Guevara EE, Eens M, Hopkins WD, Schapiro SJ, Stevens JMG, Sherwood CC, Bradley BJ. 2022. Chimpanzee Extraversion scores vary with epigenetic modification of dopamine receptor gene D2 (DRD2) and early rearing conditions. Epigenetics. 17(12):1701-1714.
Guevara EE, Hopkins WD, Hof PR, Ely JJ, Bradley BJ, Sherwood CC. 2021. Comparative analysis reveals distinctive epigenetic features of the human cerebellum. PLoS Genet. 17(5):e1009506.
Jeong H, Mendizabal I, Berto S, Chatterjee P, Layman T, Usui N, Toriumi K, Douglas C, Singh D, Huh I, Preuss TM, Konopka G, Yi SV. 2021. Evolution of DNA methylation in the human brain. Nat Commun. 12(1):2021.
Khrameeva E, Kurochkin I, Han D, Guijarro P, Kanton S, Santel M, Qian Z, Rong S, Mazin P, Sabirov M, Bulat M, Efimova O, Tkachev A, Guo S, Sherwood CC, Camp JG, Pääbo S, Treutlein B, Khaitovich P. 2020. Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains. Genome Res. 30(5):776-789.
Kozlenkov A, Vermunt MW, Apontes P, Li J, Hao K, Sherwood CC, Hof PR, Ely JJ, Wegner M, Mukamel EA, Creyghton MP, Koonin EV, Dracheva S. 2020. Evolution of regulatory signatures in primate cortical neurons at cell-type resolution. Proc Natl Acad Sci U S A. 117(45):28422-28432.
Berto S, Mendizabal I, Usui N, Toriumi K, Chatterjee P, Douglas C, Tamminga CA, Preuss TM, Yi SV, Konopka G. 2019. Accelerated evolution of oligodendrocytes in the human brain. Proc Natl Acad Sci USA. doi: 10.1073/pnas.1907982116.
Sousa AMM, Zhu Y, Raghanti MA, Kitchen RR, Onorati M, Tebbenkamp ATN, Stutz B, Meyer KA, Li M, Kawasawa YI, Liu F, Perez RG, Mele M, Carvalho T, Skarica M, Gulden FO, Pletikos M, Shibata A, Stephenson AR, Edler MK, Ely JJ, Elsworth JD, Horvath TL, Hof PR, Hyde TM, Kleinman JE, Weinberger DR, Reimers M, Lifton RP, Mane SM, Noonan JP, State MW, Lein ES, Knowles JA, Marques-Bonet T, Sherwood CC, Gerstein MB, Sestan N. 2017. Molecular and cellular reorganization of neural circuits in the human lineage. Science, 358(6366):1027-1032
Bauernfeind AL, Babbitt CC. 2017. The predictive nature of transcript expression levels on protein expression in adult human brain. BMC Genomics. 18(1):322.
Li Q, Bozek K, Xu C, Guo Y, Sun J, Pääbo S, Sherwood CC, Hof PR, Ely JJ, Li Y, Willmitzer L, Giavalisco P, Khaitovich P. 2017. Changes in lipidome composition during brain development in humans, chimpanzees, and macaque monkeys. Mol Biol Evol, 34(5):1155-1166
Duka T, Collins Z, Anderson SM, Raghanti MA, Ely JJ, Hof PR, Wildman DE, Goodman M, Grossman LI, Sherwood CC. 2017. Divergent lactate dehydrogenase isoenzyme profile in cellular compartments of primate forebrain structures. Mol Cell Neurosci, 82:137-142
Liu X, Han D, Somel M, Jiang X, Hu H, Guijarro P, Zhang N, Mitchell A, Halene T, Ely JJ, Sherwood CC, Hof PR, Qiu Z, Pääbo S, Akbarian S, Khaitovich P. 2016. Disruption of an evolutionarily novel synaptic expression pattern in autism. PLoS Biol, 14(9):e1002558
Mendizabal I, Shi L, Keller TE, Konopka G, Preuss TM, Hsieh TF, Hu E, Zhang Z, Su B, Yi SV. 2016. Comparative methylome analyses identify epigenetic regulatory loci of human brain evolution. Mol Biol Evol, 33(11): 2947-2959
Bauernfeind AL, Soderblom EJ, Turner ME, Moseley MA, Ely JJ, Hof PR, Sherwood CC, Wray GA, Babbitt CC. 2015. Evolutionary divergence of gene and protein expression in the brains of humans and chimpanzees. Genome Biol Evol, 7(8): 2276-88
Bozek K, Wei Y, Yan Z, Liu X, Xiong J, Sugimoto M, Tomita M, Pääbo S, Sherwood CC, Hof PR, Ely JJ, Li Y, Steinhauser D, Willmitzer L, Giavalisco P, Khaitovich P. 2015. Organization and evolution of brain lipidome revealed by large-scale analysis of human, chimpanzee, macaque, and mouse tissues. Neuron, 85(4):695-702
Muntané G, Horvath JE, Hof PR, Ely JJ, Hopkins WD, Raghanti MA, Lewandowski AH, Wray GA, Sherwood CC. 2015. Analysis of synaptic gene expression in the neocortex of primates reveals evolutionary changes in glutamatergic neurotransmission. Cereb Cortex, 25(6):1596-607
Bauernfeind AL, Barks SK, Duka T, Grossman LI, Hof PR, Sherwood CC. 2014. Aerobic glycolysis in the primate brain: reconsidering the implications for growth and maintenance. Brain Struct Funct, 219(4): 1149-67
Duka T, Anderson SM, Collins Z, Raghanti MA, Ely JJ, Hof PR, Wildman DE, Goodman M, Grossman LI, Sherwood CC. 2014. Synaptosomal lactate dehydrogenase isoenzyme composition is shifted toward aerobic forms in primate brain evolution. Brain Behav Evol, 83(3):216-30
Konopka G, Friedrich T, Davis-Turak J, Winden K, Oldham MC, Gao F, Chen L, Wang GZ, Luo R, Preuss TM, Geschwind DH. 2012. Human-specific transcriptional networks in the brain. Neuron, 75(4):601-17
Zeng J, Konopka G, Hunt BG, Preuss TM, Geschwind D, Yi SV. 2012. Divergent whole-genome methylation maps of human and chimpanzee brains reveal epigenetic basis of human regulatory evolution. Am J Hum Genet, 91(3): 455-65
Konopka G, Bomar JM, Winden K, Coppola G, Jonsson ZO, Gao F, Peng S, Preuss TM, Wohlschlegel JA, Geschwind DH. 2009. Human-specific transcriptional regulation of CNS development genes by FOXP2. Nature, 462(7270):213-7
Uddin M, Opazo JC, Wildman DE, Sherwood CC, Hof PR, Goodman M, Grossman LI. 2008. Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates. BMC Evol Biol, 8:8
Calarco JA, Xing Y, Cáceres M, Calarco JP, Xiao X, Pan Q, Lee C, Preuss TM, Blencowe BJ. 2007. Global analysis of alternative splicing differences between humans and chimpanzees. Genes Dev, 21(22):2963-75
Marquès-Bonet T, Cáceres M, Bertranpetit J, Preuss TM, Thomas JW, Navarro A. 2004. Chromosomal rearrangements and the genomic distribution of gene-expression divergence in humans and chimpanzees. Trends Genet, 20(11):524-9
Cáceres M, Lachuer J, Zapala MA, Redmond JC, Kudo L, Geschwind DH, Lockhart DJ, Preuss TM, Barlow C. 2003. Elevated gene expression levels distinguish human from non-human primate brains. Proc Natl Acad Sci USA, 100(22):13030-5
